| DATE | BRIEF DESCRIPTION |
| 69 BC | Born the daughter of King Ptolemy XII of Egypt. |
| 51 BC | On the death of her father, succeeds jointly to the throne of Egypt with her brother, Ptolemy XIII. |
| 48 BC | Driven into exile by supporters of Ptolemy XIII. |
| 47 BC | Julius Caesar defeats her opponents, and Ptolemy XIII is killed. Proclaimed queen of Egypt, ruling jointly with her brother, Ptolemy XIV. Gives birth to a son, Caesarion, later Ptolemy XV, claiming Caesar as the father. |
| 46 BC | Lives in Rome as Caesar's mistress. |
| 44 BC | Caesar assassinated. Cleopatra returns to Egypt. Poisons Ptolemy XIV, and makes Caesarion her co-regent. Mark Antony succeeds Caesar as joint ruler of Rome, with Octavian and Lepidus. |
| 41 BC | Summoned to meet Mark Antony; they live together for some time in Alexandria. Gives birth to their twins. |
| 36 BC | Marries Mark Antony. A third child is born. |
| 34 BC | Mark Antony announces the division of the former empire of Alexander the Great between Cleopatra and her children. |
| 32 BC | Octavian declares war on Antony and Cleopatra. |
| 31 BC | Defeated at the Battle of Actium. Antony commits suicide on hearing, falsely, of her death. |
| 30 BC | Commits suicide, rather than be exhibited as part of Octavian's triumph. |
